AACR 2023

April 14–19, 2023
Orange County Convention Center, Orlando, FL

We look forward to seeing you at AACR 2023! Join us to find out how new technology from PacBio can help you discover more complete cancer transcriptomes and genomes.

Complete the form on this page to request a meeting with us at AACR. To thank you for speaking with us, you will receive a special gift when you attend your scheduled meeting.

In the meantime, see below and refer back to this page for more on our workshop, poster presentations, and other details about PacBio at AACR 2023.

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A new age in cancer genomics: more complete transcriptomes and genomes

Description TBD

Tuesday, April 18, 2023, 10:00 – 11:00 AM
Theater D/E
Attend the workshop presentation for your chance to win a special giveaway item.


Jonathan Bibliowicz, PhD
Associate Director, Cancer Research

Opening remarks

Olga Anczukow, PhD
Associate Professor
The Jackson Laboratory

Revealing alternative splicing alterations in breast cancer using long-read RNA-sequencing

Nathan Salomonis, PhD
Associate Professor, Department of Pediatrics, Cincinnati Children's Hospital Medical Center

Understanding clonal evolution using game theory and single-cell long-read isoform analysis

Pacbio Poster Presentations

Scalable PacBio HiFi Library Prep for High-Quality Genome Assemblies

Authors: Jacob Brandenburg, Aaron Wenger, Christine Lambert, Heather Ferrao  

Jacob Brandenburg, Senior Specialist, Segment Marketing, PacBio

Long-read whole genome sequencing (WGS) for plants and animals has allowed scientists to tackle the assembly of genomes ranging in size, ploidy, and repeat content. HiFi WGS enables complete, accurate, and contiguous assemblies of even the most complex genomes. As a result, HiFi WGS has been adopted by many biodiversity genomics consortia and agriculture researchers to assemble thousands of genomes. While HiFi WGS simplifies the bioinformatics of genome assembly, library preparation remains a common challenge, especially for scientists sequencing organisms which yield low quantities of DNA or have very large genomes that require multiple libraries for a single de novo assembly. We describe a new workflow using the PacBio SMRTbell Prep Kit 3.0 that is amenable to automation while significantly reducing the time (by 50%), cost, and DNA quantity (by 40%) necessary to prepare a sequencing library. We applied the workflow to rice and fly samples and demonstrate that the assembly quality matches that of the previous, more time-consuming library prep workflows. This new workflow offers a more efficient solution for all WGS applications, regardless of organism size or complexity. 

An Evaluation of Bioinformatics Tools for HiFi Plant Pangenomes

Authors: Greg Concepcion, Michelle Vierra 

Greg Concepcion, Staff Engineer, Bioinformatics, PacBio

With the increasing prevalence of high-quality assembled genomes, access to the pangenomes of species is now an achievable possibility for researchers with all research budgets. However, the tools to visualize, analyze, and extract actionable information from these pangenome datasets are still in their infancy. Using a large plant pangenome dataset, we evaluated the pangenome graph builder  pipeline for building a pangenome graph of the species and use these evaluations to provide basic recommendations for how to best manipulate and visualize these pangenomic datasets with other downstream tools including the vg toolkit.

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Pacbio colab talk

Monday, October XX X:00 pm PST

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The poster presentation is scheduled for Monday Apr 17, 2023 from 9:00 AM - 12:30 PM
# Title First Author
LB078 pbfusion: Detecting gene-fusion and other transcriptional abnormalities using PacBio HiFi data Z. Kronenberg
P592 HiFi reads provide accurate detection of variants and DNA methylation in challenging regions of the genome G. Young
P472 Highly Scalable Pharmacogenomic Panel Testing with Hybrid Capture and Long-Read Sequencing N. Gonzaludo
P478 Simultaneous Analysis of 50+ Different Repeat Expansions with Twist Target Enrichment and PacBio HiFi Sequencing T. Han


Stop by our booth to chat with PacBio staff, get all your questions answered, and demo our new Revio and Onso sequencing systems live!​

Exhibit hours:

  • Sunday, April 16: 1:00 PM–5:00 PM

  • Monday, April 17: 9:00 AM–5:00 PM

  • Tuesday, April 18: 9:00 AM–5:00 PM

  • Wednesday, April 19: 9:00 AM–12:30 PM


Follow along @pacbio and #AACR23 on Twitter for exciting event updates!