Streamlined chromosome-scale phasing with HiFi sequencing

Tuesday, June 20, 2023
10.00 AM EDT | 3.00 PM BST | 4.00 PM CEST
Webinar

Reconstructing complete phased genomes is key to understanding the genetic basis of many complex traits. However, the bioinformatic complexity of long-range phasing creates a pressing need for streamlined, efficient computational approaches that can reconstruct high-quality, chromosome-scale phased sequences at scale.

Highly accurate long reads from PacBio (HiFi reads) are well suited for haplotype-resolved assemblies of human, non-human, and cancer genomes. With the right bioinformatics tools, HiFi data enables high-quality phased genome assembly to examine structural variant landscapes, characterize cancer-related mutations, and facilitate new, unbiased studies of haplotype variation.

In this webinar, Shilpa Garg, PhD will discuss:

The need for chromosome-scale phasing in reference genomes
Efficient and accurate haplotype-resolved human genome assembly
Generalized graph-based methods for phased assembly of cancer genomes

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SPEAKER:

Shilpa Garg, PhD
Associate Professor,
DTU Biosustain

Mark Chaisson, PhD
Assistant Professor
Computational Biology and Bioinformatics
University of Southern California
Guest speaker

Democratizing Genome Assembly and Annotation

Ted Kalbfleisch, Ph.D., Associate Professor, University of Kentucky

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Mitchell Feldmann, Ph.D., Postdoctoral Fellow, University of California, Davis.