AAV capsid discovery and design – novel sequencing approaches

  Americas/Europe broadcast: Wednesday, May 1, 9 AM PDT | 12 PM EDT | 5 PM BST

Gene therapy, particularly through rAAV vectors, has shown promising safety and efficacy across various clinical settings, signaling a paradigm shift in disease treatment. However, creating effective AAV therapeutics with minimal side effects hinges on designing novel AAV capsids for precise tissue targeting. The use of AAV capsid libraries coupled with various selection strategies has proven to be a remarkable approach to discover and design novel AAVs with enhanced and desired features. However, the inability to reliably sequence the complete capsid gene in a high-throughput manner has been the bottleneck of capsid engineering.

HiFi sequencing emerges as a critical technology in this quest, offering exceptional accuracy in sequencing the full-length AAV capsid gene. This capability is crucial for enabling whole-capsid engineering, thereby enhancing the potential safety and efficacy of gene therapy products. Our webinar will explore these innovative sequencing approaches, shedding light on their transformative potential in AAV capsid design.

Join us and embrace the future with HiFi sequencing, offering game-changing accuracy and visibility essential for groundbreaking gene therapy research.

Why attend?

  • Hear expert testimony about the practical applications of HiFi sequencing in creating novel AAV capsids, highlighting the technology’s impact on safety and efficacy.
  • Understand the intricacies of AAV whole-capsid engineering and the advantages of PacBio long reads for addressing current challenges.
  • Discover more comprehensive solutions for vector discovery, design, and characterization, setting new standards in gene therapy research.
  • Engage with a leading researcher during our interactive Q&A session, offering a unique opportunity to deepen your knowledge and apply these insights to your work.

Register for webinar

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Irvin Garza

Irvin Garza

PhD candidate
UT Southwestern Medical Center

Nadia Sellami

Nadia Sellami, PhD

Segment Lead, Gene and Cell Therapy
Host & moderator