WEBINAR
Gene therapy, particularly through rAAV vectors, has shown promising safety and efficacy across various clinical settings, signaling a paradigm shift in disease treatment. However, creating effective AAV therapeutics with minimal side effects hinges on designing novel AAV capsids for precise tissue targeting. The use of AAV capsid libraries coupled with various selection strategies has proven to be a remarkable approach to discover and design novel AAVs with enhanced and desired features. However, the inability to reliably sequence the complete capsid gene in a high-throughput manner has been the bottleneck of capsid engineering.
HiFi sequencing emerges as a critical technology in this quest, offering exceptional accuracy in sequencing the full-length AAV capsid gene. This capability is crucial for enabling whole-capsid engineering, thereby enhancing the potential safety and efficacy of gene therapy products. Our webinar will explore these innovative sequencing approaches, shedding light on their transformative potential in AAV capsid design.
Join us and embrace the future with HiFi sequencing, offering game-changing accuracy and visibility essential for groundbreaking gene therapy research.
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PhD candidate
UT Southwestern Medical Center
Segment Lead, Gene and Cell Therapy
PacBio
Host & moderator