Comprehensive variant detection in pediatric leukemia with accurate long-read whole-genome and transcriptome sequencing

The detection of genomic variants in cancer depends on an array of complementary and overlapping methods including fluorescence in situ hybridization (FISH), karyotyping, and DNA and/or RNA sequencing. The need for an "all-in-one," comprehensive genomic assay that captures all variants accurately is needed to improve variant detection, as well as reduce cost and maximize precious samples.

Accurate long-read sequencing from PacBio (HiFi sequencing) offers whole-genome and transcriptome sequencing for the detection of DNA and RNA variants, including methylation. In this webinar you will hear about how HiFi sequencing enabled the detection of variants in pediatric leukemia samples that were missed by other technologies, bringing us a step closer to the promise of a single comprehensive assay.

Watch the recording to:

Learn how accurate long-read DNA and RNA sequencing can improve the detection of somatic variants in cancer samples.
Hear about a recent study at Children’s Mercy Hospital that leverages HiFi WGS data to detect somatic variants that were missed by other technologies.

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Area(s) of interest Cancer researchOncology testing

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Speakers

Midhat Farooqi, MD, PhD

Director, Molecular Oncology, Children’s Mercy Hospital

Lisa Lansdon, PhD

Assistant Director, Molecular Genetics, Children’s Mercy Hospital

Alex Sockell, PhD

Segment Manager, Cancer Genomics, PacBio
Host and moderator