ON-DEMAND WEBINAR

HiFi on the brain – advancing Parkinson’s disease research using HiFi sequencing

Despite many years of research, relatively little is known about destructive neurodegenerative diseases such as Parkinson’s, ALS, and Alzheimer’s. Traditional methods, like short-read sequencing and microarray data, often miss critical genetic information such as structural variants, repeat expansions, methylation, and RNA isoforms—all key in driving new discoveries and identifying therapeutic targets.

In this webinar, learn about the sequencing technology that is pushing neuroscience research forward, particularly in Parkinson’s disease. Discover how HiFi whole genome sequencing (WGS) and the PacBio Iso-Seq method provide complete visibility into all genomic variants, reveal crucial transcript isoform information, and ultimately enable the potential development of novel therapeutics.

Watch the recording to:

  • Understand the challenges of DNA and RNA sequencing in neuroscience research.
  • Compare the capabilities of long-read and short-read sequencing in capturing complex genetic information.
  • Hear about the work of Dr. Mina Ryten, whose research highlights the importance of using transcript isoform information for Parkinson’s and other neurological diseases.

Don’t forget to stick around and have your questions answered during a live Q&A session!


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Speakers

Mina Ryten, MD, PhD
Clinical Professor, Honorary Consultant Clinical Geneticist, University College London, Genetics & Genomic Medicine Dept.

The splice of life: Targeting SNCA transcripts to treat Parkinson's disease

Nicole Ellis-Ovadia
Associate Director, Human Genomics, PacBio

Introductory remarks

Nadia Sellami, PhD
Segment Lead, Biopharma, PacBio

Host & moderator