WEBINAR

Detecting shared
mis-splicing across blood cancers using long-read single-cell RNA sequencing

  Americas/Europe broadcast: March 19, 9:00 AM PDT | 4:00 PM GMT
  Asia-Pacific broadcast: March 21, 9:00 AM SGT

The study of splicing dysregulation in cancer is crucial for identifying novel molecular signatures and survival associations. While splicing factor mutations are implicated in some acute myeloid leukemia (AML) cases in adults, they are uncommon in pediatric AML.

In this webinar, you will discover how long-read single-cell RNA sequencing with the PacBio Kinnex single-cell RNA kit successfully validated shared mis-splicing patterns in adult and pediatric AML. See how innovative computational approaches helped identify dominant splicing subtypes that drive disease progression, providing insight into underlying mechanisms and revealing isoform-level differences linked to disease prognosis. These findings open the door to new therapeutic targets in blood cancers, even in cases without select mutations.

Register to:

  • Understand why seeing full-length transcript isoforms is important in blood cancer research.
  • Learn how the Kinnex single-cell RNA kit offers full-length isoform information that short read RNA-Seq cannot provide.
  • See how isoform differences can drive different disease outcomes and serve as therapeutic targets.

Don’t forget to stick around and have your questions answered during a live Q&A session!


Register for webinar

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Speakers

Nathan Salomonis, PhD
Associate Professor, Cincinnati Children’s Hospital, Division of Biomedical Informatics

Alex Sockell, PhD
Segment Lead, Cancer Genomics, PacBio

Elizabeth Tseng, PhD
Associate Director, Product Marketing, PacBio

Host & moderator