AACR 2025


April 25 – 30 | Chicago, IL

Spotlight icon

Attend our spotlight theater

Hear customer speakers describe how HiFi sequencing is uncovering the hidden drivers of cancer.

Explore full program »
Booth icon

Visit booth #1042

See the Revio and Vega systems in action and chat with our experts.

Visit us »
Meeting icon

Meet with us

Book time with our team to discuss your cancer research goals and how we can support them.

Schedule a meeting »

Visit us at booth #219

Stop by our booth and chat directly with PacBio staff who will be on hand to answer your questions.


Booth hours:

  • Sunday, January 14: 12:00 PM – 8:30 PM
  • Monday, January 15: 9:30 AM – 5:00 PM
  • Tuesday, January 16: 9:30 AM – 3:00 PM

Join us at AACR

To fulfill the promise of cancer precision medicine, we need to better understand the complex biology of cancer. Join us at AACR to discover how highly accurate long- and short-read sequencing from PacBio allows you to uncover novel isoforms, fusions, and structural variants with exceptional accuracy.

Meet with us

We'd love to hear what you're working on. Fill out the form below and we'll be in touch to schedule a meeting at the conference.

By registering on this web page, you are consenting and agreeing to collection and use of your information by PacBio in accordance with its privacy policy.

SPOTLIGHT THEATER

A new day in cancer variant discovery with accurate long-read sequencing

Monday, April 28 | 12:30 – 1:30 PM Spotlight Theater B

Disentangling the molecular drivers of cancer progression requires a precise understanding of the somatic alterations that take place at the DNA and RNA level during tumor development. These include not only small changes like SNVs and indels, but also structural variants, isoforms, changes in repetitive elements, differential methylation, chromatin accessibility, and the haplotype context in which these changes occur. Existing methods lack the read length and accuracy needed to characterize these changes, while long-read sequencing with PacBio HiFi enables comprehensive profiling of all germline and somatic changes leading to cancer, even for low-input or challenging samples like FFPE.

Join PacBio to learn how highly accurate long-read sequencing is ushering in a new day in cancer genomics by enabling discovery of these variant types typically missed with short-read sequencing, to provide crucial insight into the mechanisms of cancer.
 



Speakers

 

Alex Sockell, PhD
Segment Lead, Cancer Genomics, PacBio

Arthur Dondi, PhD
Computational Biology Group, ETH Zurich

Bingqing Zhao, PhD
Snyder lab, Stanford University Department of Genetics

COLAB THEATER TALKS

CoLab #1: Exploring the potential clinical utility of HiFi sequencing for homologous loci (pseudogenes)

Date/Time: Thursday, November 2 | 10:10 – 10:40 AM EDT

Location: Walter E. Washington Convention Center, Exhibit Hall, CoLab Theater #2

Alexander Hoischen, PhD
Assistant Professor, Radboud University Medical Centre


PacBio HiFi long-read sequencing has the potential to become a single front-line assay for interrogating rare disease cohorts because of its ability to accurately call and phase all classes of variants. An international group of clinical researchers and PacBio have been collaborating to study the efficacy of HiFi sequencing in interrogating the many possible genetic mechanisms that underlie rare diseases. This presentation will provide an overview of the group’s goals and activities and will share recent results, particularly around correctly resolving clinically relevant genes that lie in areas of high sequence homology or otherwise complex regions of the human genome.

CoLab #2: Expanding NGS truth sets with long-reads: more comprehensive variant detection in a multi-generational pedigree

Date/Time: Friday, November 3 | 10:10 – 10:40 AM EDT

Location: Walter E. Washington Convention Center, Exhibit Hall, CoLab Theater #2

David Porubsky, PhD
Post-Doctoral Fellow, University of Washington, Eichler Lab

Zev Kronenberg, PhD
Senior Manager, Computational Biology, PacBio





Accurate long-read sequencing characterizes the full spectrum of genetic variation across the genome, but variant calling software is still catching up to the sequencing technologies. We have generated deep Pacific Biosciences (PacBio) high-fidelity (HiFi), ultra-long Oxford Nanopore Technologies (ONT), Strand-seq, and Illumina whole-genome sequencing data to construct near-T2T, phased genome assemblies from primary material obtained from a 4-generation, 28-member CEPH pedigree (1463). We are constructing a more comprehensive and validated catalog of >8 million single-nucleotide variants, indels, short tandem repeats, and structural variants, including a detailed assessment of inversion polymorphisms that associate with disease risk. The use of multiple orthogonal technologies, near-T2T phased-genome assemblies, and a multi-generation family allow us to assess inheritance patterns and to create a “truth set” for all classes of human genetic variation upon which to test and benchmark new technologies.

PRESENTATIONS

  • Poster Title Presenter Date | Time
    Abstract #6288 | Section 46, poster 2 Precise characterization of complex repeat regions in cancer genomes Khi Pin Chua, PhD Tues., April 29 | 2:00 - 5:00 PM
    Abstract #6624 | Section 10, poster 5 Comprehensive, multi-omic detection of somatic variants from the GIAB HG008 matched tumor-normal pair Alex Sockell, PhD Wed., April 30 | 9:00 AM - 12:00 PM

Visit us at booth #1042

Stop by our booth to chat directly with PacBio staff and get hands-on demonstrations of our sequencing systems. We are excited to answer your questions and explore tailored solutions for your research!


Booth hours:

  • Sunday, April 27: 12:00 – 5:00 PM
  • Monday, April 28: 9:00 AM – 5:00 PM
  • Tuesday, April 29: 9:00 AM – 5:00 PM
  • Wednesday, April 30: 9:00 AM – 12:00 PM

PacBio service providers

Interested in getting a sequencing project started? Stop by our service providers to talk about project design and next steps.

Booth 211

Booth 212

Booth 213

Booth 214

Get AACR updates on Bluesky
Follow us
Discuss your project with us at AACR
Book a meeting
Speak to a sequencing specialist
Contact us

Get In Touch

Speak to a sequencing specialist
Contact us
Discuss your project with us at ASHG
Book a meeting

Get In Touch

Get in touch with us about a thing
Have at it