Cancer Breakthroughs: An Interactive HiFi Experience

Reveal cancer variants hiding in plain sight

Cancer is driven by more than single nucleotide changes. Structural variants. RNA isoforms. Gene fusions. Methylation changes. Repeat expansions. Phased mutations. Chromatin architecture.

But many of these critical drivers are invisible to short-read sequencing.

Discover how PacBio HiFi sequencing reveals the full spectrum of cancer variation in a single assay. 

What you’ll explore in this interactive experience:

  • RNA isoforms that can help predict survival and immunotherapy response
  • Novel gene fusions missed by standard diagnostic research tests
  • Structural variants undetectable with short reads
  • Tumor-specific neoantigens revealed by full-length transcripts
  • Native methylation patterns acting as second hits
  • Phased mutations linked to drug response
  • Repetitive regions and microsatellite instability with single-base precision
  • Chromatin accessibility profiled at single-molecule resolution

 

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See real research examples across lung, breast, ovarian, colorectal, gastric, pediatric cancers, sarcoma, and retinoblastoma.

One platform. One assay. A complete view of cancer biology.

Download the interactive experience.

Explore how researchers are uncovering hidden cancer drivers with HiFi sequencing and how you can apply it in your own work.

Pamela Nicholson

NGS Platform Head, University of Bern

David Stucki

Field Applications Support, PacBio

Geoff Henno
Associate Director, Precision Health, PacBio
Host and moderator